LB Patrick Queen vs. RB Najee Harris

Queen has extra motivation in this game stemming from a rookie season run-in with Mike Tomlin. Queen will have plenty of run-ins with Harris on the field, however, as the Steelers' powerful back is still a key part of their engine. Baltimore must tackle well and stop him before he gets started.

RT Morgan Moses/replacement vs. OLB T.J. Watt

The Ravens should win if they take care of the football. Watt has the potential to be a game-wrecker as the Ravens are well aware, as he has 12 sacks in 12 games against Baltimore. He's at the top of his game against this year, tied for the league lead with 6.0 sacks. Moses is coming off a shoulder injury but could still suit up. If he doesn't, it will be veteran Patrick Mekari or Daniel Faalele.

QB Lamar Jackson vs. S Minkah Fitzpatrick

Fitzpatrick is the Steelers' other potential difference-maker on defense. He had six interceptions last season but is still looking for his first this year. Jackson hasn't played his best in three games against the Steelers and Fitzpatrick will try to lure him into a mistake.

CB Marlon Humphrey/replacement vs. WR George Pickens

It remains to be seen whether Marlon Humphrey will return to the field after just three days of practice this week. The Ravens would love to have his physicality in this rivalry. Pickens is a strong, tall receiver who can make spectacular catches. If the Steelers offense is going to come alive, it will probably be Pickens providing the spark.

OLB Jadeveon Clowney vs. LT Broderick Jones

Clowney is among the league leaders in quarterback pressures and he's looking to finish more for sacks. With veteran Dan Moore Jr. (knee) injured, Jones is expected to start his first career game. The Steelers first-round rookie was a mauler at Georgia, but he's facing a savvy veteran who is hungry to turn pressures into sacks.