QB Lamar Jackson vs. S DeShon Elliott
Elliott spent his first three years in Baltimore before bouncing around the last few seasons. The 27-year-old has made an impact in Pittsburgh with 64 tackles, four passes defensed, and one interception. Now Elliott and the rest of the Steelers secondary has to stop the MVP favorite in Jackson, who has 24 touchdowns and just two interceptions this season.

WR Diontae Johnson vs. CB Donte Jackson
After playing his first five seasons in Pittsburgh, Johnson will get to see the other side of the rivalry Sunday. Johnson only has one catch with the Ravens since getting traded from the Panthers at the end of October, but revenge will be on his mind against the Steelers. Jackson has three interceptions and six passes defensed this season, and he will try to keep Johnson quiet in his return to the Steel City.

CB Marlon Humphrey vs. WR George Pickens
In three games with Russell Wilson under center, Pickens has 276 yards and two touchdowns, bringing in 85% of his targets. He had 91 yards and an absurd touchdown grab against the Commanders last week. Humphrey, who has been one of the league's best cornerbacks this season, will spend a lot of time on Pickens in the AFC North clash.

RB Derrick Henry vs. LB Patrick Queen
Henry and Queen were major topics around Baltimore all offseason after Queen left for the division rivals and Henry joined the Ravens. Henry is second in the NFL with 1,120 rushing yards while Queen has had some ups and downs so far in Pittsburgh. A Henry run right at Queen would be must-see TV.

RT Roger Rosengarten vs. LB T.J. Watt
Rosengarten has his toughest test yet as a pro facing one of the league's best edge rushers. Watt leads the NFL with four forced fumbles and has 6.5 sacks after leading the league with 19 last season. Rosengarten has settled in well since entering the starting lineup in Week 3, and Sunday will be a huge opportunity for the rookie.