RB Derrick Henry vs. Chiefs Defense

After months of holding back in practice, Derrick Henry can finally let loose. Kansas City's defense has a tough ask to stop Henry, who has averaged more than 100 rushing yards per game against the Chiefs in his career.

Ravens O-Line vs. DT Chris Jones

The Ravens have three new starters on the offensive line, and they will be tasked with guarding one of the best interior rushers in the NFL. Jones had 10.5 sacks last season and 15.5 the year before. He'll move all along the line and be a big first test for Baltimore's protection.

S Kyle Hamilton vs. TE Travis Kelce

One of the games' brightest young stars covering a first ballot Hall-of-Famer will be must-see TV. Kelce caught a touchdown against Hamilton in the AFC Championship last year, but Hamilton will have his shot to get back at him on Thursday.

CB Nate Wiggins vs. WR Xavier Worthy

The matchup of two first-round rookies will be speed vs. speed. Worthy set the Combine record, running the 40-yard dash in 4.21 seconds, and Wiggins was just behind him at 4.28 seconds. It's unknown how much each will play, but when they face off, expect some deep shots.

QB Lamar Jackson vs. QB Patrick Mahomes

While Jackson and Mahomes won't be guarding each other, how could a matchup of two multiple-time MVPs not make the cut? Mahomes has won back-to-back Super Bowls and Jackson is searching for his first. The hunt for Super Bowl LIX starts with them on Thursday.