DT Justin Madubuike vs. RG Brandon Scherff

Madubuike has registered at least a half-sack in 10 straight games, one short of tying the NFL record. Scherff is one of the top-ranked guards in the league, per Pro Football Focus. Madubuike is an important piece of pressuring Trevor Lawrence and making sure he doesn't break the pocket to pick up first downs with his legs.

CB Marlon Humphrey vs. WR Calvin Ridley

Ridley is the Jaguars' clear top receiver. He had a season-high 13 targets last week. Humphrey is coming off an up-and-down game in which he gave up a couple big completions late in the game. Ridley is known for his smooth route-running and he can go off if he gets hot.

RT Morgan Moses vs. OLB Josh Allen

Allen's 13.5 sacks are tied for the third-most in the NFL, only trailing Khalil Mack and T.J. Watt. The Ravens rotated Moses with Daniel Faalele last week and it remains to be seen whether they'll do the same with Allen up next.

WR Odell Beckham Jr. vs. CB Tyson Campbell

Campbell is arguably the Jaguars' top cornerback and has missed three of the past four games due to a hamstring injury. He returned to practice this week and appears on track to return. Beckham has been on a hot streak and is coming off a season-high 97-yard performance last week.

LB Patrick Queen vs. RB Travis Etienne

If there's been one weakness in the Ravens defense this year, it's been the run defense, which ranks No. 12 (104.2 yards per game). Etienne has the fifth-most rushing yards in the league (806) and is also a threat as a receiver. Queen has competed against Etienne since their youth as two Louisiana boys.