CB Marlon Humphrey vs. WR Ladd McConkey

Having arguably the best season of his career, Humphrey will match up against Los Angeles star rookie McConkey, who plays the majority of his snaps in the slot. The 34th-overallpick has 615 receiving yards and four touchdowns, emerging as a top target for Justin Herbert. Baltimore's pass defense took a step in the right direction in Week 11, and Humphrey will try to keep that going by quieting McConkey.

TE Mark Andrews vs. S Derwin James

Andrews' slow start is in the rearview mirror now and he continues to be a safety blanket for Lamar Jackson. Andrews only had two catches last week but has been a key piece to Baltimore's offense over the last month. James is still one of the game's top safeties and helps lead Los Angeles' league-leading defense.

LT Ronnie Stanley vs. OLB Joey Bosa

Stanely has been spectacular this season and the tough matchups just keep coming. Bosa has missed time this year but is still one of the game's fiercest edge rushers. He has three sacks in seven games. Bosa moves around the line but will have a ton of reps against Lamar Jackson's blindside blocker.

S Kyle Hamilton vs. QB Justin Herbert

Herbert is thriving in Greg Roman's offense while Hamilton is showing last season wasn't a fluke. The chess match between Herbert and Hamilton will be fun to watch as the Ravens look to bounce back from a tough loss to the Steelers.

ILB Trenton Simpson vs. RB J.K. Dobbins

With Roquan Smith's status in the air, Simpson could have a bigger role in the middle of the defense Monday. He'll have a few former teammates on the other side including Dobbins, who's having his best season as a pro. After injury-plagued years in Baltimore, Dobbins has 726 yards and eight touchdowns in his first season with the Chargers.