CB Brandon Stephens vs. WR Michael Pittman Jr.

Stephens did an outstanding job against Bengals wide receiver Ja'Marr Chase last week. Now he'll probably see a lot of the Colts' top receiver. Pittman leads Indianapolis in receiving yards by a large margin with 153 through two games. He's a big-bodied receiver at 6-foot-4, 223 pounds.

DT Michael Pierce vs. LG Quenton Nelson

Nelson has gone to the Pro Bowl all five of his years in the league. Pierce led Baltimore's defensive linemen in snaps last week, and if the Ravens are going to snuff out Zach Moss and the running game, Pierce must have a strong showing against one of the game's best.

C Sam Mustipher vs. NT Grover Stewart

Mustipher is friends with a couple of the Colts' offensive linemen, including Nelson. The Ravens center, who seems likely to step in for Tyler Linderbaum for a second week, said he's heard that Stewart is a major pain to block. Stewart is a monster at 6-foot-4, 314 pounds. Head Coach John Harbaugh said this week that he was a player the Ravens loved in the 2017 draft.

LG John Simpson vs. DT DeForest Buckner

Buckner is the Colts' top pass rusher, as he's logged 26.5 sacks the past three seasons and already has two this year. He's another physical specimen, standing in at 6-foot-7, 287 pounds. The Colts' defensive front is their strength. For the Ravens to stay balanced on offense, they need to control these big defensive linemen.

WR Zay Flowers vs. CB Kenny Moore II

Flowers has gotten off to a hot start, showing his ability to make defenders miss in space and blow past them going deep. With Odell Beckham Jr. dealing with an ankle injury, Flowers could have an even bigger role in the Ravens' receiving attack. Moore is one of the better slot cornerbacks in the NFL, however.