Buffalo Bills at Baltimore Ravens, October 2, 2022
In the first of three home games during the month of October, the Ravens battle the Bills at M&T Bank Stadium on October 2. Buffalo is the fourth AFC East opponent that Baltimore will play in its first four weeks of the season, marking the first time in franchise history that the Ravens open the season facing an entire division in consecutive games. This is the first matchup with the Bills since the Ravens' 2020 Divisional Playoff loss in Buffalo.